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T. Leonard

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Open access Jul 2026

Dimerization-dependent cis-autophosphorylation activates the UPR and ISR kinases

Maintaining cellular homeostasis requires the ability to detect and respond to various forms of stress. Protein kinases of the unfolded protein response (UPR) monitor protein folding in the endoplasmic reticulum, while the integrated stress response (ISR) kinases sense viral infection, nutrient deprivation, mitochondri...

Magdalena Otto, T. Leonard · 0 citations

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