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Open access Aug 2026

Cutaneous Alpha-Synuclein Deposition Informs Autonomic Function in Individuals with Early-Stage Multiple System Atrophy

Purpose: Multiple system atrophy is a progressive neurodegenerative disorder characterized by autonomic failure, parkinsonism, and cerebellar ataxia. Phosphorylated alpha-synuclein in skin nerves has emerged as a promising biomarker, but longitudinal studies remain limited. This study evaluated changes in cutaneous alp...

P. Trujillo, Leah G. Mann, B. Bellaire et al. · 0 citations
Review Open access Aug 2026

Clinical utility of skin biopsy detection of phosphorylated alpha-synuclein in an outpatient practice

Introduction The neurodegenerative disorders characterized by deposition of phosphorylated alpha-synuclein (P-SYN) include Parkinson’s disease (PD), multiple system atrophy (MSA) and dementia with Lewy bodies (DLB). Diagnosis of synucleinopathies in clinical practice has been enhanced by recent updates to diagnostic gu...

T. Levine, R. Freeman, N. Murray et al. · 0 citations

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