Open access
Jul 2026
Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development
It is demonstrated that postnatal deletion of Yin Yang 1 (Yy1) in PCs disrupts dendrite and spine formation, impairs synaptic plasticity, and alters protein kinase C gamma (PKCγ) expression, leading to cerebellar ataxia and progressive atrophy.
Lam-Lui Ying, Xiao-Nan Dong, T. C. Leung et al.
· iScience · 0 citations