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Open access Sep 2026

X-Admix: An Interpretable Multimodal Cross-Attention Framework for Integrating Genotype, Local Ancestry, and Social Drivers of Health in Admixed African American Populations

Disease risk in admixed human populations is shaped by interactions among genotype, locus-specific ancestry, and the social environment, but predictive frameworks rarely model these three modalities jointly. We introduce X-Admix, an interpretable multimodal framework integrating genotype, local ancestry, and social dri...

N. Tahmin, L. Chinthala, T. Mersha et al. · 0 citations
Open access Sep 2026

Multi-Ancestry Genome-wide Association Analyses Identify Shared and Specific Genetic Architecture in Mild and Moderate-to-Severe Asthma

Background: Moderate-to-severe asthma affects 15-30% of asthma patients, but accounts for over 50% of healthcare costs and disproportionate morbidity. However, the genetic mechanisms underlying moderate-to-severe versus mild asthma remain poorly understood. Methods: We performed separate pooled multi-ancestry GWAS of m...

A. Mendy, Yadu Gautam, Birch Rosen et al. · 0 citations

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