Open access
Aug 2026
Spatiotemporal dynamics of the tumor microenvironment in hepatocellular carcinoma during combination immunotherapy
The exploratory findings suggest that ATZ/BEV may remodel the HCC microenvironment toward a state characterized by concurrent CD8+ T-cell activation and inhibitory signaling through the TIGIT–PVR/NECTIN2 axis, particularly at the tumor margin.
Hitoshi Iwasaki, S. Itoh, K. Toshida et al.
· Hepatology Communications · 0 citations