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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

T. Muranen

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Open access Sep 2026

A noncanonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer

Resistance to standard-of-care therapies remains a major clinical challenge in the treatment of the most common breast cancer, the hormone receptor–positive (HR+) subtype. Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors improve outcomes in early-stage HR+ disease, yet many patients relapse. Resistance mechanisms of rel...

Jenny M. Hogstrom, Hanna M. Doh, A. Kump et al. · 0 citations
Open access Jul 2026

Multi-modal data integration reveals functionally credible predictive biomarkers in ovarian cancer.

An integrated whole-genome and transcriptome workflow is developed to systematically distinguish functionally credible, predictive driver aberrations from non-functional alterations across all classes of genomic events in ovarian high-grade serous carcinoma.

T. Muranen, A. Hainari, D. Afenteva et al. · 0 citations

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