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T. Nguyen

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Review Open access Sep 2026

Beyond phenotypic markers: rethinking dopaminergic identity in iPSC-derived neurons

Human pluripotent stem cell-derived dopaminergic neurons have become central platforms for Parkinson’s disease (PD) modeling and regenerative medicine. Current differentiation systems can efficiently generate TH+/FOXA2+/LMX1A+ ventral midbrain-like populations. Although canonical markers remain important components of...

Duc-Hiep Bach, T. Nguyen · 0 citations
Review Open access Jul 2026

CAR-T and TIL therapies in solid tumors: barriers, clinical lessons, and convergent solutions

The approval of lifileucel in 2024 marked an important milestone in oncology as the first cellular therapy authorized for a solid tumor and a review of the biological obstacles, emerging convergence strategies, and translational frameworks including biomarker-guided patient selection that define this new area.

Duc-Hiep Bach, Van T. Hoang, T. Pham et al. · 2 citations
Review Jul 2026

CAR-T Cell Therapy: Manufacturing Platforms and Clinical Consequences.

A three-layer mechanistic framework is presented that reframes manufacturing as biology: integration biology determines genomic risk and transgene stability; clonal fitness shapes persistence, dominance, and exhaustion; and epigenomic imprinting preconfigures functional trajectories.

Duc-Hiep Bach, T. Nguyen · 0 citations

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