Colon-targeted oral delivery of melatonin for regulating macrophage activity and intestinal barrier in ulcerative colitis
Background Despite its promising therapeutic potential, inefficient site-specific targeting and complex fabrication processes hinder the clinical translation of oral melatonin therapy for ulcerative colitis (UC). Herein, we present Melatonin-Eudragit-Thioketal polymer-based Assembly (META), a dual pH/ROS-responsive ora...