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T. Okusaka

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Review Open access Oct 2026

Recent advances in systemic therapy for biliary tract cancer: Evidence from Japan and recommendations in guidelines.

Systemic therapy for biliary tract cancer (BTC) has evolved substantially over the past two decades. Gemcitabine plus cisplatin was established as the global standard first-line regimen, followed by further optimization through alternative doublets, intensified triplet chemotherapy, and the recent introduction of immun...

T. Okusaka, J. Furuse, Masaru Konishi et al. · 0 citations
Sep 2026

Molecular Subtyping of Biliary Tract Neuroendocrine Carcinomas: Clinicopathological Features and Prognostic Implications.

Neuroendocrine carcinoma (NEC) of the biliary tract is an exceptionally rare and highly aggressive malignancy, and its molecular subtype landscape and diagnostic boundaries remain poorly defined. We retrospectively analyzed 42 biliary tract NECs, including 22 surgically resected cases, arising in the intrahepatic bile...

Yumi Asai, Minoru Esaki, Satoshi Nara et al. · 0 citations

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