T. Pischon

Effects of short-term exposures to air temperature and temperature variability on blood pressure and heart rate in the German National Cohort

Temperature variability (TV) is an emerging cardiovascular risk factor, yet the independent effects of air temperature (aT) and TV on hemodynamic parameters in European populations remain unclear. To investigate the association of short-term aT and diurnal TV individually and jointly with systolic (SBP) an...

Exposure to childhood adversity and adult alcohol, nicotine, and illicit drug use in Germany: a cross-sectional analysis of the German National Cohort (NAKO)

Rationale Exposure to adversity in childhood and adolescence (i.e., “early-life stress”; ELS) is a well-established risk factor for substance use. Objectives The aim of this study was to investigate associations between ELS exposure and substance use across subtypes of ELS, different substance classes, and behavioral p...

Statistical methods for analyzing change over time of continuous outcomes in observational health studies: a scoping review of suggested approaches

A scoping review of methodological studies proposing strategies to address bias when analyzing within-person change in continuous outcomes and of applied observational studies to examine analytical practice following PRISMA guidelines and PROSPERO registration provides a structured framework to support more transparent...

Meal-induced changes in cardiometabolic peptides in the context of acute cardiovascular diseases and glucose metabolism

Usual dietary intake estimation in the German National Cohort (NAKO)

Introduction Accurate measurement of dietary intake remains challenging in large-scale nutritional studies. This study aimed to develop and evaluate both a practical dietary assessment strategy and a computationally efficient statistical method for estimating usual dietary intake in the German National Cohort (NAKO Ges...

Environmental exposures and mental health: longitudinal results from the German National Cohort (NAKO).

BACKGROUND Environmental exposures such as air pollution, population density, and climate-related stressors may influence mental health, yet large-scale longitudinal evidence is limited. This study examined associations of environmental exposures with depressive and anxiety symptoms, and stress in the German National C...

The association of a lifestyle risk index with glycemic status in the German National Cohort (NAKO)

In this large sample of predominantly healthy adults, a combination of lifestyles, foremost driven by not smoking, was weakly associated with lower HbA1c levels but not self-reported diabetes, and lifestyle factors may be relevant for glycemic control.

Volumetric reference data of the orbit: a deep learning MRI analysis in the German national cohort

This deep learning tool effectively resolved the bottleneck of manual segmentation, providing comprehensive orbital reference data for the German population and enabling future high-throughput epidemiological research into the associations between orbital anatomy, systemic health, and disease.