Author

T. Roumeliotis

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Open access Sep 2026

Mechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges

The BTRR (BLM/TOP3A/RMI1/RMI2) complex resolves DNA replication and recombination intermediates, as well as mitotic DNA intertwinements, yet how its diverse activities are regulated remains unclear. Here, we identify key determinants of stable assembly of the BTRR complex on ultrafine DNA bridges (UFBs). We reveal that...

U. Aliyaskarova, Özgün Özer, Mahafuzul Sumon et al. · bioRxiv · 0 citations

Open access Aug 2026

RNA terminal uridylyl transferases are druggable vulnerabilities in AML but are dispensable for normal hematopoiesis

Together, these findings identify TUT4/7 as druggable targets, whose inactivation suppresses AML while sparing normal hematopoiesis, and represents a promising therapeutic strategy in combination with venetoclax.

Christopher Mapperley, Elise Georges, A. Azar et al. · Science Advances · 0 citations

Open access Sep 2026

BCOR mutations establish a persistent culture-adaptive state in human induced pluripotent stem cells

It is demonstrated that correction of BCOR mutation by CRISPR–Cas9 only partially restores the wildtype molecular state, highlighting the importance of early detection and monitoring of adaptive mutations in hiPSC cultures.

C. Badja, S. Boushaki, Yogesh Kumar et al. · bioRxiv · 0 citations