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Review Open access Oct 2026

Cancer of Unknown Primary in Transition: From Empirical Chemotherapy to Immunotherapy and Molecularly Guided Treatment.

Cancer of unknown primary (CUP) is a heterogeneous group of metastatic malignancies in which the primary site remains unidentified despite appropriate diagnostic evaluation. Historically, most patients with unfavorable CUP have received empirical platinum-based chemotherapy, but recent advances in immune checkpoint inh...

T. Sagawa, Masahiro Hirakawa, H. Nagashima et al. · 0 citations

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