T. Semmler

Genomic signatures highlight stress-response evasion and translational tuning as key drivers of Escherichia coli adaptation to fluorinated tryptophans

Fluorinated amino acids profoundly perturb cellular physiology because they enter the proteome while differing from their natural counterparts in subtle but functionally important ways. Here we investigated how Escherichia coli adapts to the biosynthesis and proteome-wide incorporation of fluorinated tryptophans derive...