Author

T. Terooatea

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Open access Oct 2026

Additive-input encoding fails operator-level target-held-out prediction on current Perturb-seq screens

Pooled Perturb-seq screens are often interpreted through a linear steady-state model in which each targeted gene supplies an additive perturbation input. Although this formulation identifies an operator on the observed response subspace in closed form, identifiability alone does not establish that inferred operators ge...

Kyler J. Fullmer, Dalton Kutzen, T. Terooatea · bioRxiv · 0 citations

Open access Aug 2026

Time-resolved operator archetypes characterize dynamical sensitivity during cell-state transitions

During development, cells traverse gene expression states where their local dynamical sensitivity changes sharply, yet existing computational methods provide limited access to when and where this sensitivity peaks along a trajectory. Here we introduce scJDO (single-cell Jacobian Differential Operators), a framework tha...

David M. Redd, Samuel G. Green, T. Terooatea · bioRxiv · 0 citations