Open access
Jul 2026
Preformed Fibril Seeding Reshapes the Phosphorylated α-Synuclein Proximal Proteome in the Olfactory Bulb
Background Aggregated alpha-synuclein (αsyn) phosphorylated at serine 129 (PS129) accumulates in synucleinopathies, with the olfactory bulb (OB) being severely affected. Non-aggregated physiological PS129 is abundant in the mammalian OB, where it likely modulates αsyn-protein interactions. The impact of aggregation on...
Solji G. Choi, Atousa Bahrami, Jayda B. Duvernay et al.
· bioRxiv · 0 citations