Author

T. Tree

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Open access Oct 2026

TRICALS risk score augments but cannot replace neurofilament as a prognostic biomarker in ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with substantial clinical heterogeneity, complicating the design and interpretation of clinical trials. Two strategies have been proposed to address this variability: phenotype-based prognostic modelling and biomarker-based stratification using neurofi...

Ahmad Al-Khleifat, A. Malaspina, J. Kirby et al. · Journal of Neurology · 0 citations

Clinical trial Open access Aug 2026

IL-2 mutein-engrafted antibody MHS552 selectively expands functional regulatory T cells in nonclinical models and healthy participants

Low-dose interleukin-2 (IL-2) shows potential for treating autoimmune disorders by expanding regulatory T cells (Treg), but therapeutic utility is limited by short half-life and off-target effects. Here, we describe the molecular design, nonclinical development, and first-in-human study of MHS552, an IL-2 mutein-engraf...

Igor Radanović, Michael DiDonato, A. Meijs et al. · Nature Communications · 0 citations