Author

T. Tsubone

3 papers indexed here

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Review Open access Sep 2026

Assessing photodynamic therapy under in vitro hypoxia: photochemical pathways and methodological challenges

Photodynamic therapy (PDT) is a light-activated modality that kills cells through photosensitizer-triggered reactive oxygen species, but its efficacy is strongly shaped by oxygen availability and by whether photochemistry proceeds through Type I or Type II pathways. In oxygen-rich settings, Type II PDT mainly generat...

I. V. da Cunha, M. Caetano, N. Bessas et al. · Biophysical Reviews · 0 citations

Open access Aug 2026

Piperazine and Morpholine Protoporphyrin IX Derivatives Intensify Biomolecules Oxidation and Phototoxicity in Triple‐Negative Breast Cancer

Photodynamic therapy (PDT) is a clinically established approach that relies on the localized generation of reactive oxygen species (ROS) mediated by a photosensitizer (PS), light, and molecular oxygen. Protoporphyrin IX (PpIX) is an approved PS; however, its intracellular retention is limited, factor that can alter its...

Maynne Duarte Suriani Franco, Thibault Joseph William Jacques Dit Lapierre, Tarcísio Paiva Mendonça et al. · ChemMedChem · 0 citations

Open access Sep 2026

Effects of Mono‐ and Dicapsaicinoid Functionalization on the Physicochemical Properties and Antimicrobial Photodynamic Activity of Protoporphyrin IX

Antimicrobial photodynamic therapy (aPDT) is a promising alternative for combating multidrug‐resistant bacteria and overcoming limitations of conventional antimicrobial treatments. To improve aPDT performance, two Protoporphyrin IX (PpIX) derivatives functionalized with one or two capsaicin fragments were synthesized a...

I. V. da Cunha, G. G. Calefi, N. B. S. Silva et al. · ChemMedChem · 0 citations