Author

T. Ulas

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Open access Aug 2026

Microglia activation by derepression of endogenous retroviruses drives inflammation and cellular senescence.

Aging-associated loss of chromatin compaction is linked to derepression of retrotransposable elements (RTEs) in mouse and human tissues. Whether such RTE transcription contributes to the microglia activation that is common in aged brains is unknown. Here, we show that DAXX, a histone chaperone and RTE repressor, is dow...

Xin Yan, Christina Georgopoulou, Hang-Mao Lee et al. · Nature Neuroscience · 0 citations

Open access Aug 2026

metadeconfoundR: covariate analysis of high-dimensional cross-sectional omics data

Identifying disease biomarkers from large molecular datasets is complicated by correlated and confounded signals like comorbidities and treatment regimens, batch effects, and cohort biases. These effects bias statistical inference and clinical conclusions. Robust methodologies are fundamental for reliable biomark...

T. Birkner, Chia-Yu Chen, Morgan Essex et al. · Bioinformatics Advances · 0 citations