Author

T. Van Loy

3 papers indexed here

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Open access Sep 2026

High-affinity ELR+ CXC chemokines display balanced G protein-, GRK- and β-arrestin-associated transducer engagement at the viral G protein-coupled receptor ORF74

Open reading frame 74 (ORF74) is the single G protein-coupled receptor (GPCR) encoded in the genome of Kaposi’s sarcoma-associated herpesvirus (KSHV). Due to its high constitutive activity and broad chemokine binding profile, ORF74 contributes to KSHV-associated diseases through autocrine and paracrine mechanisms tha...

Qian-Qian Kong, Brent Van Bosstraeten, S. de Jonghe et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Synthesis and evaluation of 3,5-disubstituted isothiazolo[4,5-b]pyridines, pyrazolo[4,3-b]pyridines and isothiazolo[3,4-b]pyrazines as inhibitors of PIKfyve

Among the newly synthesized scaffolds, the isothiazolo[3,4-b]pyrazines were the most promising, displaying potent and selective PIKfyve inhibition in a biochemical assay, and, in addition, showing antiviral activity against SARS-CoV-2 (in the low μM range).

Ling-Jie Gao, M. Froeyen, Chieh-Wen Lo et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

Identification of CXCL13 as an agonist and CXCL11 as an inverse agonist for the viral G protein-coupled receptor ORF74.

CXCL13 and CXCL11 are revealed as two additional chemokine ligands for ORF74, further expanding the pharmacological profile of this viral GPCR.

Qian-Qian Kong, Brent Van Bosstraeten, S. de Jonghe et al. · Biochemical Pharmacology · 1 citation