KIF1A-Mediated Axonal Transport of Netrin-1 in iPSC-Derived Human Forebrain Neurons.
Netrin-1 is a secreted laminin-like protein that functions as a guidance cue for axon pathfinding in development. Netrin-1 also modulates synapse formation in developing neurons and long-term potentiation in mature neurons. Netrin-1 is expressed in human neurons; however, its intracellular distribution and trafficking...