The TEA domain transcription factors TEAD1 to TEAD4 integrate Hippo signaling with transcriptional programs that govern tissue homeostasis and cancer progression. Their activity is shaped by cofactor engagement, palmitoylation, chromatin organization and extracellular cues, creating therapeutic vulnerabilities that v...
Metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction and alcohol-related liver disease (MetALD) exist on a continuous spectrum in which fibrosis stage remains the dominant predictor of liver‑related complications. Contemporary non‑invasive risk stratification uses simple serum scor...
Hua-Peng Lin, Hai-Xia Wang, Kang-Sen Yang et al.· Clinical and Molecular Hepat...· 0 citations
This narrative review examines the transition from task-specific discrimination AI to large language models (LLMs), multimodal foundation models, and agentic AI, and outlines the future directions for safe AI model deployment based on multimodal foundation models, prospective and federated evaluation, lifecycle governa...
Na-Na Peng, Mary Yue Wang, S. J. Song et al.· Clinical and Molecular Hepat...· 0 citations
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