Tadamitsu Kishimoto

Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation.

Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflammatory mediators, including Interleukin-6 (IL-6), thereby amplifying inflammation. However, structural basis and regulatory mechanisms of Arid5a func...