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Author

Taekjip Ha

2 papers indexed here

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Open access Sep 2026

A superfamily 1 helicase translocates on double-stranded DNA

Replicative and accessory helicases are essential for maintaining genome integrity during DNA replication and repair. Rep helicase belongs to superfamily 1 (SF1), the first helicase family solved at atomic resolution and a longstanding model for how helicases couple ATP hydrolysis to movement on DNA. Using optical twee...

Sushil Pangeni, A. Nakara, Olivia Yang et al. · 0 citations
Open access Aug 2026

Direct visualization of MCM helicase activation and replisome coupling in situ

Deciphering the spatial organization of molecular machines that copy the genome remains a fundamental challenge in biology. Essential for eukaryotic DNA replication, Mini-Chromosome Maintenance (MCM2-7) helicases are loaded during G1 as double hexamers (DHs) to license replication origins. Upon activation in S phase, e...

O. Zinder, Jonas Zähringer, Hana Polasek-Sedlackova et al. · 0 citations

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