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Author

Taidong Lyu

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University

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Open access Sep 2026

Persistent Zn2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn2+‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the molecular mechanism underlying this proc...

Yu-Xin Jin, Yong-Cheng Chen, Yi-Hao Xie et al. · 0 citations
Jul 2026

Pathology-Responsive Self-Assembling Hydrogel Enabling Spatiotemporally Controlled Exosome Release and Redox Regulation for Intervertebral Disc Regeneration.

A pathology-adaptive self-assembling hydrogel that exploits dynamically varying catabolic enzyme activity to trigger on-demand delivery of antioxidant molecules and bioactive extracellular vesicles leads to significant structural and functional recovery of the damaged disc, as strongly evidenced in vivo animal studies.

Zhan Gao, Gan Lyu, Qiwei Zhou et al. · 0 citations

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