Associating a Polygenic Risk Score for Multiple Sclerosis with Brain MRI Metrics and Cognitive Performance in Healthy UK Biobank Participants.
PURPOSE Multiple sclerosis (MS) is a demyelinating disease of the central nervous system influenced by both genetic and environmental factors. Although a polygenic risk score for MS (MS-PRS) is associated with disease susceptibility, its relationship with white matter (WM) microstructure and cognition in neurologically...