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Author

Takahira Yamauchi

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Open access Oct 2026

Developmental prefrontal myelination shapes inhibitory interneuron function and adult social behavior

Early-life adversity and abnormal myelination are implicated in psychiatric disorders, but how developmental myelination influences adult social cognition remains unclear. Here, we tested whether disrupting developmental myelination in the medial prefrontal cortex (mPFC) impairs adult social behavior. Using complementa...

Takahira Yamauchi, Kohei Kamikawa, Kazuhiko Yamamuro et al. · 0 citations
Review Open access Sep 2026

Guanfacine and HCN channels: bridging neuroinflammation and prefrontal cortex function in autism spectrum disorder

Background Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication differences and restricted, repetitive behaviors. Convergent evidence implicates prefrontal cortex (PFC) circuit dysregulation and chronic neuroimmune activation in ASD. Despite increasing off-label use of...

Kazuhiko Yamamuro, Takahira Yamauchi, Manabu Makinodan · 0 citations
Open access Jul 2026

Linking auditory brain responses to cortical microstructure and sensory behaviors in autism spectrum disorder: a preliminary study

The preliminary and exploratory findings tentatively suggest that microstructural variability in the temporal cortex and OFC may relate to auditory neural responses and to sensory and cognitive features of ASD, but these results should be regarded as hypothesis-generating rather than confirmatory.

N. Kashida, Kazuhiko Yamamuro, K. Matsuoka et al. · 0 citations

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