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Author

Takahiro Tsuno

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Oct 2026

Small-molecule modulation of VDAC enhances glucose-stimulated insulin secretion by promoting ATP flux.

Reduced insulin secretion by β cells is a pivotal factor in diabetes onset and progression. The small molecule NPD976 was identified as a potent insulin secretagogue using high-throughput chemical screening employing an insulin secretion assay system. Even part of the molecular structure of NPD976, designated as DPEU (...

Kohichi Matsunaga, K. Honda, Muneeb Ali et al. · 0 citations

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