The Expanding Roles of B Cells in Systemic Sclerosis: From Autoantibody Production to Antibody-Independent Functions and Therapeutic Targeting
Systemic sclerosis (SSc) is a rare, clinically heterogeneous connective tissue disease defined by the triad of autoimmunity, microvasculopathy, and fibrosis of the skin and internal organs. Among the immune effectors implicated in SSc, B cells have moved from being regarded mainly as the source of disease-defining auto...