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Author

Takashi Miki

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Oct 2026

GLS2 Promotes Early Ferroptosis Followed by Apoptosis and p53 Signaling in Renal Ischemia-Reperfusion Injury.

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI), particularly in the settings of kidney transplantation and perioperative care. In IRI-induced AKI, ferroptosis, an iron-dependent, lipid peroxidation-driven form of regulated cell death, occurs early in proximal tubular epithelial ce...

Kazuki Ishiwata, Sawako Suzuki, Chi-Wei Lee et al. · 0 citations
Open access Jul 2026

Notch signaling pathway mediates anti-inflammatory effects of vagus nerve stimulation during lipopolysaccharide-induced acute kidney injury.

Using a mouse model of lipopolysaccharide (LPS)-induced AKI, it is found that CAP activation by vagus nerve stimulation (VNS) enhanced Notch2 signaling in macrophages, mitigating inflammation in the spleen and tissue damage in the kidneys, thereby protecting the kidneys.

Shuhei Kuwabara, Hiro Inoue, W. Nash et al. · 0 citations

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