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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Takashi Saika

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Open access Jul 2026

Enzalutamide promotes an early plasticity-associated transcriptional state without terminal neuroendocrine differentiation in prostate cancer cells

It is suggested that enzalutamide preferentially enhances early lineage plasticity rather than bona fide NEPC differentiation and provide a framework for distinguishing adaptive transcriptional reprogramming from true neuroendocrine lineage conversion in treatment-emergent prostate cancer.

R. Watanabe, M. Chosei, Haruna Arai et al. · 0 citations
Review Open access 2026

Cellular plasticity and tumor ecosystem dynamics in prostate cancer: insights from single-cell and spatial transcriptomics.

Recent discoveries from single-cell and spatial analyses are summarized, their implications for biomarker development and treatment stratification are discussed, and ongoing technical challenges are outlined, including standardization, reproducibility, and clinical scalability.

R. Watanabe, T. Chu, N. Miura et al. · 2 citations

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