Takehiko Ito

Successful clinical remission of severe asthma with small airway dysfunction and eosinophilic gastrointestinal disease using dupilumab after benralizumab failure

Background Small airway dysfunction (SAD) is an underrecognized but important feature of severe asthma, contributing to persistent symptoms and treatment resistance. Biologics targeting type 2 inflammation vary in their efficacy for SAD, and comorbid eosinophilic gastrointestinal disease (EGID) may further complicate m...