HLA-DRB1*08:03-associated exocrine–endocrine immune linkage: a pathogenic mechanism in ketosis-prone type 2 diabetes
Abstract Context Unprovoked ketosis-prone type 2 diabetes (KPD) is characterized by a male predominance, young age of onset, and abrupt presentation of diabetic ketosis/ketoacidosis without precipitating factors. Although many individuals regain β-cell function after insulin therapy, some progress to insulin dependence...