Author

Takeyuki Tamura

2 papers indexed here

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#artificial intelligence Preprint Oct 2026

HGPRGDel: GPR-Aware Learning and Ranking for Growth-Coupled Gene Deletion Design

This work presents a reproducible protocol for growth-coupled gene deletion design that learns and ranks gene-deletion priorities for each target metabolite, and provides a reproducible framework for reusing strain-design knowledge while controlling the size of the candidate space and retaining mechanistic evaluation o...

Zi-Wei Yang, Takeyuki Tamura · 0 citations

Preprint Sep 2026

Decoding enzyme-substrate interaction topology reveals principles underlying catalytic efficiency and mutational outcomes

The enzyme turnover number (kcat) defines catalytic efficiency and constrains quantitative models of metabolism, yet the molecular determinants governing kcat and its response to mutation remain poorly understood. Measurements are sparse and labor-intensive, and most computational approaches provide numerical predictio...

Wei-Ren Zhao, Takeyuki Tamura · 0 citations