Open access
Jul 2026
Role of Pbr1, a putative oxidoreductase, in the ER quality control and folding of yeast Fks1 glucan synthase
It is shown that PBR1 operates at the endoplasmic reticulum to support the folding and stability of Fks1, enabling proper cell-wall assembly and reveals an ER quality-control mechanism that enables constrained membrane proteins to fold efficiently and perform essential cellular functions.
Keisuke Obara, Hiroki Okada, Guihong Tan et al.
· Proceedings of the National... · 1 citation