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The renal proximal tubule is a primary target of drug-induced toxicity due to its high metabolic activity, dense mitochondrial content, and central role in xenobiotic uptake and handling. Injury to this nephron segment is a major contributor to acute kidney injury development, which is associated with substantial morbi...
This work explores the applicability of new approach methodologies (NAMs) using a read-across approach to predict systemic toxicity with liver as the critical target organ, and derive a point of departurefor the target compound (TC) difenoconazole. Eight conazoles were used as source compounds (SCs), alongside metaboli...
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