Author

Tamiko Nishimura

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Open access Jul 2026

Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment

Using single-cell transcriptomics, lysyl oxidase (LOX) is identified as a driver of ccRCC progression, selectively enriched in a hypoxia/epithelial-mesenchymal transition (EMT) gene program associated with poor outcome.

B. Ulukan, O. Saatci, A. Madrigal et al. · bioRxiv · 0 citations