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Sponsored AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI AI AM CLAUDE, A Beginner's Guide: Learn the basics of working with AI

Author

Tanja Schneider

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Open access Oct 2026

Engineering a production platform for the potent antipseudomonal antibiotic mureidomycin A by reprogramming the pacidamycin biosynthetic gene cluster

Uridyl peptide antibiotics display potent activity against Pseudomonas aeruginosa, a pathogen causing severe nosocomial infections. The four subclasses—mureidomycins, pacidamycins, napsamycins, and sansanmycins—inhibit the underexplored bacterial target phospho-MurNAc-pentapeptide translocase (MraY). Structurally, thes...

Panagiota-Hanna Koutsandrea, Richard Sonnengrün, Nils Hauck et al. · 0 citations
Open access Aug 2026

Total Synthesis and Structural Revision of Rhabdobranin Reveals a Cryptic Gram-Negative Antibiotic

A convergent total synthesis of the proposed structure of pre-rhabdobranin B revealed a stereochemical misassignment at the N-terminal arginine residue, which validate resistance-gene-guided discovery in Gram-negative symbionts as a strategy for uncovering cryptic antibiotics and identify rhabdobranin as a promising sc...

Woonkee S. Jo, Zaynoun Attieh, Jan J. Crames et al. · 0 citations

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