Tantianpact

Preclinical Basal Ganglia Neurodegeneration in Female X Linked Dystonia Parkinsonism Carriers

Background and Objectives: X-linked dystonia-parkinsonism (XDP) is a severe neurodegenerative movement disorder caused by a retrotransposon insertion with a polymorphic hexanucleotide repeat expansion in the TAF1 gene. While the disease predominantly affects males, female carriers may exhibit a variable phenotypic expr...