Author

Tanuja Chitnis

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Open access Sep 2026

Genome-wide association analyses highlight the neuronal contribution to multiple sclerosis susceptibility

Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.

Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al. · Nature Genetics · 0 citations

Open access Aug 2026

Metabolomics reveals lipid and amino acid signatures of disease severity in multiple sclerosis

Findings highlight coordinated dysregulation of amino acid and lipoprotein metabolism as hallmarks of established MS and identify a novel association of the omega-6/omega-3 ratio with inflammatory disease activity.

Rachel E. Rodin, B. Healy, Mariann Polgár-Turcsányi et al. · bioRxiv · 0 citations