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Author

Tanvi Kulkarni

2 papers indexed here

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Open access Jul 2026

Transcription initiation drives dosage compensation establishment and maintenance in male Drosophila

Dosage compensation (DC) in Drosophila equalizes X chromosome–linked gene expression via the male-specific lethal complex, which acetylates histone 4 lysine-16 on the male X chromosome. How DC is established during early embryogenesis remains obscure, largely due to the difficulty of obtaining sufficient sex-specific m...

Ronald Oellers, A. Alexiadis, Yidan Sun et al. · 0 citations
Open access Aug 2026

Genome-wide CRISPR screening identifies cellular factors controlling nonviral genome editing efficiency

To systematically map cellular factors constraining nonviral genome editing, influencing uptake and intracellular trafficking, we develop a genome-wide CRISPR screening platform linking perturbation of 19,114 genes to editing outcomes in human cells. We identify six negative regulators of delivery whose depletion incre...

Shivani Saxena, Meha Kabra, Amr A. Abdeen et al. · 0 citations

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