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Sep 2026

Machine‐Learning‐Guided DNAzyme Nanocages for Photoresponsive Immunomodulation and Spatiotemporal Control of Diabetic Bone Regeneration

Inflammation poses a therapeutic paradox, as cytokine signals driving inflammatory disease can also provide transient repair cues. Effective intervention therefore requires selective suppression of pathogenic mediators and control over inhibition timing. RNA‐cleaving DNAzymes are well suited as transcript‐selective c...

Nanxin Liu, Meng-Jiao Huang, Can Shen et al. · 0 citations
Open access Sep 2026

Hierarchical Nanoplatform Integrating Oxidative–Acidic Microenvironment Remodeling and Bone Homeostasis Modulation for Diabetic Bone Defect Therapy

ABSTRACT Diabetic craniofacial bone defects exhibit unsatisfactory repair attributed to synergistic oxidative stress, local acidification and disordered bone immunity, whereas conventional mono‐functional biomaterials are incapable of synchronously resolving these interlocked pathological cascades. Herein, a hierarchic...

Xu Chen, Xing-Yu Zhu, Zhixin Qiu et al. · 0 citations
Open access Aug 2026

Osteogenic Outcomes and Associated Modifiable Factors of 3D-Printed Individual Titanium Mesh Exposure: A Retrospective Analysis.

OBJECTIVE To identify independent risk factors for titanium mesh exposure following 3D-printed individualized titanium mesh (3D-PITM)-assisted alveolar bone augmentation and to evaluate the impact of exposure on bone regeneration outcomes. METHOD This retrospective study included 52 patients with severe alveolar bone...

Minxue Yang, YaXin Bai, Yu-Ling Yang et al. · 0 citations

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