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Author

Tao Chen

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Open access Aug 2026

Decitabine suppresses triple-negative breast cancer by disrupting DNMT1 liquid-liquid phase separation and synergizes with G9a inhibition

This study reveals DNMT1 LLPS as a druggable vulnerability in TNBC and establishes LLPS disruption as a promising therapeutic strategy, providing a rationale for combining epigenetic inhibitors to treat TNBC and other cancers with high DNMT1 expression.

Mei-Lin Hu, Hao-Jie Peng, Guo-Chang Qiu et al. · 0 citations
Open access Sep 2026

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

ABSTRACT Coronaviruses have persistently triggered global pandemics in the 21st century, featuring either high transmissibility or high pathogenicity. A hallmark of these infections is the delayed activation of innate immune responses, resulting in dysregulated antiviral signaling and uncontrolled viral replication. Mu...

Li-Xiang Xie, Zi-Ye Huang, Zhi-Yuan Zhang et al. · 0 citations
Open access Sep 2026

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

RHS is established as a generalizable strategy for overcoming viral immune evasion and advancing next‐generation vaccine design, and is readily adaptable to antigens from SARS‐CoV and MERS‐CoV, underscoring its versatility for pan‐coronavirus vaccine development.

Xi-Kui Sun, Junhao Fan, Xiaolu Xie et al. · 0 citations

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