Aberrant expression of the lymphoid antigen CD7 is observed in acute myeloid leukemia (AML) and correlates with adverse clinical outcomes. However, its biological role and mechanistic contribution to treatment failure remain unclear. Here, we systematically characterized CD7 expression across AML subtypes and dif...
Chen-Shuo Ren, Nan Shao, Ye Yuan et al.· Journal of Experimental &...· 0 citations
Activating mutations in FMS-like tyrosine kinase 3 (FLT3) drive aggressive acute myeloid leukemia (AML) and confer poor prognosis. Although FLT3 inhibitors have improved outcomes, their efficacy is frequently limited by microenvironment-mediated signaling and treatment-emergent resistance. XY0206 is a structurally opti...
Long Shen, Yang Yang, Cheng-Hua Xu et al.· Journal of Clinical Investig...· 0 citations
Acute myeloid leukemia (AML) is the most common acute leukemia in adults. Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) stands as a leading curative approach for AML in China. However, relapse remains a major challenge for patient survival, often occurring within six months post-transplant and ass...
A panoramic landscape of the human hematopoietic system is established and its lifelong behaviors are elaborated, in which a steady-state reference enabled the delineation of pathological hallmarks across hematological malignancies.
Xiao-Wei Xie, Lian-Shuo Li, Fang Hong et al.· Protein & Cell· 0 citations
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