Open access
Jul 2026
Structural Mechanisms of DNAJC13 Dimeric Assembly and InsP6 binding in Recycling Endosome Regulation
It is shown that DNAJC13 forms an unexpected antiparallel homodimeric architecture involving distinctive symmetrical interactions between composite IWN1 and α-solenoid ARM2 domains in each protomer, which provides a structural and mechanistic framework for understanding DNAJC13 function in recycling endosome control.
Tao Fu, Chan Lee, Frances V. Hundley et al.
· bioRxiv · 0 citations