Tao Li

Ion Mobility-Collision Induced Unfolding Detects Stability Shifts within Hidden Protein Conformer Families

Proteins commonly exist in complex mixtures, adopting a diverse ensemble of structural conformations. While some of these conformations are functionally important, others (e.g., preaggregative states), can adversely affect protein function. In monoclonal antibody (mAb)-based biotherapeutics such structural polydisper...