Open access
Aug 2026
Bacteria-Mediated Targeted Delivery and Deep Tumor Penetration of a Pt(IV)-Drug Enables Synergistic Chemo-Immunotherapy.
Platinum-based drugs are clinically vital for cancer treatment but suffer from off-target cytotoxicity and poor tumor penetration. To overcome these limitations, we designed a tumor-targeted Pt(IV) drug-bacteria conjugate (Pt-EcN-HER2). This conjugate exploits the inherent tumor tropism of probiotic bacterium Escherich...
He Meng, Jin-Hui Wang, Bing Shi et al.
· Angewandte Chemie · 0 citations