Tao-Sheng Chen

Emerging Roles of Mass Spectrometry-Based Proteomics in Drug Discovery.

Mass spectrometry (MS)-based proteomics has emerged as a versatile platform in modern drug discovery, enabling system-wide interrogation of protein abundance, posttranslational modifications (PTMs), turnover, structural stability, and interactions with small molecules in native biological contexts. In this review, we i...

BRD4 recruitment into HP1 condensates desilences transcription without erasure of repressive chromatin

Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development

The authors identify a binding site on the Sonic Hedgehog signaling protein Smoothened for the allosteric regulator arachidonic acid (AA) and show that its disruption attenuates SHH- and sterol-stimulated SMO induction.