Sep 2026
FDX1-short proteoform induces caspase-independent cell death in tumor cells.
Jing-Xia Han, Yu Sun, Zhen Yang et al.
· Cell Death and Differentiati... · 0 citations
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Sep 2026
Targeted dual degradation of GPC-3 and VEGFR with multivalent DNA nanoflower-based LYTACs for hepatocellular carcinoma therapy.
While targeted therapies for hepatocellular carcinoma (HCC) have advanced, their clinical benefits remain constrained by limited efficacy, off-target toxicity, and the frequent emergence of drug resistance and recurrence. To address these challenges, we developed a multivalent DNA nanoflower-based dual-targeting LYTAC...
Ping Zhou, Jin-Zhi Zang, Jia-Xuan Wang et al.
· Journal of Controlled Releas... · 0 citations
Open access
Aug 2026
XPO1-mediated TRIM21 nuclear export reprograms TREM2+ macrophage polarization by targeting IRF3 to augment anti-PD-1 efficacy in small cell lung cancer
An XPO1-TRIM21-TNFSF15 axis is defined that promotes the polarization of immunosuppressive TREM2+ macrophages, which ultimately orchestrates immune exclusion by impairing antigen presentation and enhances the efficacy of anti-PD1 immunotherapy in mice.
Qing-Wu Du, Ting-Ting Qin, Jing-Ya Wang et al.
· Nature Communications · 0 citations