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Review Open access Sep 2026

PERK signalling in neurodegenerative diseases: From ER stress to mitochondrial dysfunction and therapeutic opportunities

The PERK (PKR-like endoplasmic reticulum kinase) pathway is a key branch of the unfolded protein response (UPR), and is crucial for maintaining cellular homeostasis. In neurodegenerative diseases, factors such as misfolded protein accumulation and oxidative stress lead to sustained endoplasmic reticulum stress, thereby...

Tao Xu, Sheng-Wei Jing, Jing Wu · 0 citations
Open access Sep 2026

6-Gingerol Regulates the Exosomal miR-148b-3p/ACSL4/Ferroptosis Axis in an in vitro Model of Diabetic Retinopathy

Background Diabetic retinopathy (DR), a leading cause of blindness, is driven by redox imbalance and ferroptosis in retinal endothelial cells. While 6-Gingerol exhibits antioxidant properties, its role in modulating exosome-mediated redox signaling in DR remains unexplored. This study investigates whether 6-Gingerol pr...

Shuang Liu, Juan Ye, Long-Chang Suo et al. · 0 citations

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