How gene expression programs are coordinated across space and time to build a complete plant remains poorly understood. Here, we combine high-resolution spatial transcriptomics, single-nucleus RNA sequencing, and a gap-free reference genome to build a 3D spatiotemporal atlas of rice, spanning 10 organs and 61 stages fr...
Yi Jing, Qiong Chen, Yi-Fan Chen et al.· Cell· 1 citation
The cellular innovations underlying vertebrate gastrointestinal diversification remain largely unknown. Here, we constructed a single-cell and spatial transcriptomic atlas comprising nearly 1 million cells from 10 species, spanning 500 million years of vertebrate evolution. Analysis of conserved gene co-expression modu...
A comprehensive transcriptomic and chromatin accessibility atlas of 8 brain regions of 23 female cynomolgus macaques spanning the adult lifespan, including exceptionally old individuals establishes a foundational framework for understanding the cellular and regulatory architecture of primate brain aging and its links t...